Endocrine Abstracts

A 56-year-old woman presented with an acute onset of left sided ptosis, diplopia and failure of upward gaze almost 20 years after conventional pituitary irradiation for a growth hormone secreting tumour. Her visual fields were full. Visual acuities were 6/9 in the right eye and 6/6 in the left eye. She had a complete left third nerve palsy. She was growth hormone deficient and had primary hypothyroidism, hypercholesterolemia and hypertension. These were well controlled on trea...

A 39-year-old woman presented at 23 weeks gestation with extreme fatigue and non-specific neurological symptoms. Other than mild hypertension her physical examination was normal. Serum calcium was 3.36 mmol/l (normal 2.12–2.62) and phosphate 0.8 mmol/l (Normal 0.8–1.5). She was severely hypercalcemic throughout pregnancy and her corrected calcium ranged between 2.82 and 3.48 mmol/l. Other investigations included 25 hydroxy-Vitamin D3 98 (normal 75–200...

A 45-year-old woman was diagnosed with hypothyroidism at 26, Addison’s disease at 35 and primary ovarian insufficiency at 42. She is positive for adrenal and thyroid microsomal antibodies but negative for ovarian antibodies. She has a strong family history of autoimmunity. Interestingly, her mother has pernicious anaemia and hypothyroidism and her sister has hypothyroidism. A diagnosis of autoimmune polyglandular syndrome (APS) type 2 has been supported by the HLA haploty...

A 74-year-old gardener developed progressive dysphagia for solids and liquids over 15 months. He lost five stone in weight and became increasingly weak. There was nothing significant in his past medical and drug histories. He is married, never smoked and drank little alcohol.He had an acute medical admission via A&E in April 2008 for profound dehydration and cachexia. His weight was 41.5 kg. There were no gross neurological deficits but he had hoarse...